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James Carson, PhD, FACSM
Chair, Exercise Science Department

Associate Director, The Center for Colon Cancer Research at USC

Director of Integrative Muscle Biology Laboratory
Division of Applied Physiology

University of South Carolina
Department of Exercise Science
Public Health Research Center, Rm 301
921 Assembly Street
Columbia, SC 29208

Phone: (803) 777-2185
Fax: (803) 777-0558
E-mail: carsonj@mailbox.sc.edu

BS, The Ohio State University, 1985

PhD, The Ohio State University, 1993. Dr. Steve Alway, advisor. 1989-1993 .

Post-Doctoral Research Fellow, U. Texas Medical School Houston, Physiology. Dr. Frank Booth PI.1993-1997.

Post-Doctoral Research Fellow, Baylor College of Medicine, Cell Biology, Dr. Robert Schwartz PI.1997-1999.

Assistant Professor, Department of Exercise Science, Arnold School of Public Health, University of South Carolina.1999-2005

Associate Professor, Division of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina. 2005 - 2011

Professor, Division of Applied Physiology, Department of Exercise Science, University of South Carolina. 2011 - present

Director of Graduate Studies, Exercise Science Department, 2007 - 2014

Chair, Exercise Science Department. University of South Carolina. 2014 - present
My "Integrative Muscle Biology Laboratory" employs molecular biology techniques with in vivo and in vitro models examining muscle plasticity. Currently my laboratory is examining signaling induced by disease or altered loading, which can differentially regulate gene expression in skeletal muscle. Specifically, my laboratory is interested in hormonal and nutritional interactions with these regulatory processes. Our research will impact counter measures for patient's with chronic wasting diseases, age-related loss of skeletal muscle mass, as well as, the maintenance of muscle mass during space missions, and the general practice of resistance training.
Current Projects
IL-6 regulation of muscle wasting during cancer cachexia: The role of protein turnover and mitochondria function

Testosterone and estrogen induced mechanisms that regulate muscle regeneration after injury

Inflammation regulation of muscle plasticity induced by overload and disuse.

Completed PhDs as Chair

Aditi Narsale, 2014.
Currently a Post Doctoral Fellow Penn State Medical School, Hershey PA. Department of Immunology. PI: Dr. Channe Gowda.

Melissa Puppa, 2013.
Currently a Post Doctoral Fellow St. Judes Childrens Research Hospital, Memphis TN, Department of Developmental and Neurobiology, PI: Fabio Demontis

Suichi Sato, 2012.
Currently a Post-doctoral Research Fellow, University of Louisville Medical School, Department of Anatomical Sciences and Neurobiology; PI: Dr. Ashok Kumar

Kandy Velasquez, 2012.
Currently a Post Doctoral fellow USC School of Medicine

Jim White, 2011.
Originally went on to a Post-Doctoral Fellowship at the Dana-Farber Cancer Institute. Department of Cell Biology, Harvard Medical School; PI: Dr. Bruce Spiegelman. Currently Research Associate at Duke Medical School

Tyrone Washington, 2008.
Currently a Tenure Track Assistant Professor, University of Arkansas

Ray Thompson 2007.
Currently Clinical Assistant Professor Faculty, University of South Carolina

Kristen Mehl-Baltgalvis, 2007.
Originally went on to a Post-Doctoral Fellowship with Dr. Dawn Lowe at the University of Minnesota. Currently: Senior Scientist, Rigel Pharmaceuticals

Joseph McClung, 2005.
Originally went on to a Post-Doctoral Fellowship at the University of Florida with Dr. Scott Powers. Currently: faculty East Carolina School of Medicine, Physiology Dept.
EXSC 223 Anatomy & Physiology I
EXSC 695 Reading & Writing in Research
EXSC 499 Undergraduate Laboratory Research
EXSC 781: Physiology, Exercise, and Disease
EXSC 783 Research Seminar in Exercsie Science
EXSC 785 Advanced Laboratory Techniques in Exercise Science
EXSC 880: Myology
Cordinator Exercise Science Seminar Series 2001 - present

Google Scholar Report November 2014
Current h-index 36
Citations: 3,215
10-index (publications with at least 10 citations): 66
8 articles cited over 100 times

Research gate: https://www.researchgate.net/profile/James_Carson2/?ev=hdr_xprf

selected from over 80 refereed research publications

Mentorship: * denotes student author

Leadership: + denotes senior author

Velazquez, K.T.*, R.T. Enos*, A. Narsale*, M.J. Puppa*, J.M. Davis, E.A. Murphy, and J.A. Carson+. Quercetin supplementation attenuates the progression of cancer cachexia via IL-6/STAT3 signaling pathway. J Nutrition (In Press 2014). - Impact factor 4.20

Puppa, M.J.*, E.A. Murphy, R Fayad, G.A. Hand, and J.A. Carson+. Cachectic Skeletal Muscle Response to a Novel Bout of Low Frequency Stimulation. J Appl. Physiol. (in Press) 2014. - 5 yr. impact factor 4.138 .

Hardee, J.P.*, C. Porter, L.S. Sidosis, J.A. Carson, D.N. Herndon, and O.E. Suman. The role of early rehabilitative exercise training I nthe revcovery from pediatric burn. Med Sci. Sports Exercise (in Press) 2014. - 5 yr. impact factor 4.475

Puppa, M.J.*, S. Gao*, A.A. Narsale*, and J.A. Carson+.Skeletal Muscle glycoprotein 130s role in Lewis Lung carcinoma-induced cachexia. FASEB Journal (in Press) 2014. - 5 yr. impact factor 6.22

White J.P.*, M.J. Puppa.*, Gao S.*, Sato S.*, S.L. Welle and J.A. Carson+. Disrupted mTOR Signaling During Cancer Cachexia: A role for AMPK. American J Physiol. Endocrine Metab. 304(10): E1042-52 2013. PMCID: 3651620 - 5 yr. impact factor 4.828; 5 citations

Lima, M.*, S. Sato*, R.T. Enos*, J.W. Baynes, and J.A. Carson+. Development of an UPLC-mass spectrometry method for measurement of myofibrillar protein synthesis: application to analysis of murine muscles during cancer cachexia. J Applied Physiol. 114 (6): 824-828, 2013 PMCID 3615602 - 5 yr. impact factor 4.138; 2 citations

White, J.P*. S Gao*, M.J. Puppa*, S. Sato*, S.L. Welle, and J.A. Carson+. Testosterone regulation of Akt/mTORC1/FOXO3a Signaling in Skeletal Muscle. Molecular & Cellular Endocrinology. 365(2): 174-186 2013. PMCID 3529800 - 5 yr. impact factor 3.347; 13 citations

Mannie, N.D.P.K., M. Lima*, R.T. Enos*, P. Wehner, J.A. Carson, and E. Blough. Altered cardiac muscle mTOR regulation during the progression of cancer cachexia in the Apc Min/+ mouse. International J. Oncology. 42(6): 2134-40, 2013 PMCID 23589074 - 5 yr. impact factor 2.80

Recent Book Chapters & Reviews

J.A. Carson & M. Puppa*. Biological Pathways Impacting Cancer Survival: Exercise as a countermeasure for the development and progression of cachexia. (eds) C. Ulrich, K Steindorf, N Berger. Exercise, Energy Balance and Cancer. Series: Energy Balance and Cancer. 2012