Applied Biosystems 3730 DNA Analyzer
EnGenCore offers mid-to-high throughput DNA sequencing on a traditional platform using the 48-capillary 3730. In addition to running BigDye Terminator-based reactions, the 3730 is also available for DNA fragment analysis. Combined with data analysis software and convenient, electronic data delivery, consider the 3730 for your next sequencing project.

ABI 3730 DNA Sequencing FAQ (PDF)
Fees

Roche/454 Genome Sequencer FLX
Do you need to sequence a de novo genome, characterize microbial communities using 16S rRNA, survey a suite of genes associated with cancers, or metagenomic analysis of environmental samples? If so, our Roche/454 FLX system and trained staff are here for you. Our facility offers the full range of Roche/454 FLX services generating up to 100 million base pairs in a single run. A full software suite is available for mapping, assembly, and amplicon analysis.

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Affymetrix GeneChip Instrument System
EnGenCore offers a complete platform for use with Affymetrix GeneChip probe arrays and Custom Genotyping assays. Included are a hybridization oven, two fluidics stations capable of washing/staining up to 8 arrays, a 48-array capacity scanner, and GeneChip Operating Software for data acquisition and analysis. Applications include expression analysis, transcript discovery, resequencing, and genotyping. EnGenCore is able to prepare targets for hybridization to over 50 different commercially-available probe sets from over 30 different species.

Affymetrix GeneChip® Instrument FAQ (PDF)
Fees

Applied Biosystems 7900HT QRT-PCR System
The 7900 is a fast (as little as 35 minutes for 96-well format), high-throughput real-time PCR system for quantitating nucleic acid sequences. Key applications include gene expression quantitation and SNP detection. Combined with powerful quantification software, EnGenCore is able to deliver quality data from RNA, cDNA, or DNA samples.

ABI 7900 RT-PCR FAQ (PDF)
Fees

Linux Computer Cluster
To support the bioinformatics needs of its clients, EnGenCore offers customized data analysis using a Linux-based computer cluster consisting of sixty-four 2.2 GHz processors. Comprehensive base calling, sequence editing, contig assembly, genome assembly, gene mapping, and whole genome mapping is offered through the Phred, Phrap, Consed, Newbler, and FlowMapper software. Local copies of the NCBI and KEGG databases are routinely updated allowing fast BLAST homology searches for both large and small scale DNA sequencing projects using Paracel BLAST software.

EnGenCore Linux cluster FAQ (PDF)
Fees
 

Leica TCS SP5 Confocal Microscope
EnGenCore offers state-of-the-art imaging using the Leica TCS SP5 confocal microscope. The TCS SP5 tandem scanner combines two technological solutions in one system: a conventional scanning system - ideal for morphological imaging and three dimensional structure analyses, and a resonant scanning system - the best solution for high speed confocal imaging. For demanding multiparameter fluorescence imaging, this microscope is equipped with high efficiency SP-detection (five channels simultaneously). The TCS SP5 also provides fluorescence lifetime imaging (FLIM) capability.

Leica TCS SP5 Confocal Microscope FAQ (PDF)
Fees

Bruker Senterra Dispersive Raman Microscope
The Senterra is a full-featured confocal system that can accommodate multiple excitation wavelengths with the highest possible spatial resolution. This system is based on the Olympus BX51 optical microscope and contains all the necessary tools for sample visualization and characterization. The incorporated RamanScopeIII provides fluorescence-free, non-destructive Fourier transform Raman excitation to the same microscopic spot as the Senterra. This combination provides full spectroscopic characterization and optimizes the strengths of the both techniques for your complex micro-analysis samples.

Bruker Senterra Dispersive Raman Microscope FAQ (PDF)
Fees